Description:

The blood-brain barrier (BBB) is composed of specialised endothelium which physically separates the central nervous system from brain microvasculature, and prevents movement of many substances between the two. Only a very limited number of molecules are able to cross the BBB including those that are lipid soluble, those for which there are specific transport systems and small molecular weight molecules (below about 500 Daltons), making drug delivery to the brain a real challenge. The aim of this meeting was to provide an update on BBB endothelial cell (patho)physiology and function and to discuss novel approaches CNS drug delivery. Meeting's Chair: Dr Charlotte Lawson, Royal Veterinary College, UK.