Polyphenols are chemicals found in many plants. Polyphenols are usually antioxidants that can protect cells from oxidative damage caused by free radicals. Many polyphenols have anti-obesity activities and are beneficial for weight loss. Aging and obesity may lead to inflammatory and oxidative conditions. Inflammation and oxidative stress are also important pathological factors in obesity-related diseases such as diabetes, fatty liver, cardiovascular diseases, and cancer. Polyphenol extracts from fruits and herbs such as apples and green tea can inhibit inflammation, lower blood cholesterol and glucose levels, and reduce risks of heart diseases. These natural antioxidants can be used as dietary supplements without evident adverse effects. The latest discoveries and studies of cellular and molecular mechanisms of such polyphenols suggest that they can be potential agents for the treatment of obesity and associated diseases. (Journal of Personalized and Systems Medicine)...More >< Less