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Theoretical Studies of Structure-Function Relationships in Kv Channels: Electrostatics of the Voltage Sensor

eBook (PDF), 46 Pages
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Voltage-gated ion channels mediate electrical excitability of cellular membranes. Reduced models of the voltage sensor of Kv channels produce insight into the electrostatic physics underlying the response of the S4 transmembrane domain to changes in membrane potential. By calculating the partition function computed from the electrostatic energy, I compute expectations of charge displacement, energetics, probability distributions of translation & rotation and Maxwell stress for S2, S3 & S4 arrangements. A ‘paddle’ model is rejected on electrostatic grounds. On the other hand, a ‘sliding helix’ model with three local counter-charges, a protein dielectric coefficient of 4 and a 2/3 interval of counter-charge positioning relative to the S4 α-helix period of positive residues is electrostatically reasonable, comparing well with Shaker. These ‘sliding helix’ models compare favorably with experimental results for mutant charge... More > experiments on Shaker. Movies: https://sites.google.com/site/alexpeyserthesis< Less
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Product Details

Published
September 27, 2011
Language
English
Pages
46
File Format
PDF
File Size
6.99 MB

Formats for this Ebook

PDF
Required Software Any PDF Reader, Apple Preview
Supported Devices Windows PC/PocketPC, Mac OS, Linux OS, Apple iPhone/iPod Touch... (See More)
# of Devices Unlimited
Flowing Text / Pages Pages
Printable? Yes
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