An integrative dynamic systems approach to understanding Src family kinase signalling

eBook (PDF), 222 Pages
This item has not been rated yet
Price: Free
This Ph.D. project focussed on protein interactions involved in the regulation of the tyrosine kinase Src, which plays a major role in a number of signal transduction pathways. From the multitude of known protein interactions described in the literature, a differential equations model was defined and analysed. The simulations provided insights into systems-level properties of the network, namely a robust, bistable switch and excitable behaviour. A Monte Carlo investigation of the parameter space was used to quantify the robustness of the network and to assess the likelihoods of two alternative models, representing mechanistic hypotheses inspired from literature. A further study addressed issues relating to the interface between Src family kinases and several receptor tyrosine kinases. The model serves as a coherent and quantifiable description of Src family kinase signalling events and makes novel, experimentally testable predictions.
Available in PDF Format

Ratings & Reviews

Log in to review this item
There are no reviews for the current version of this product
There are no reviews for previous versions of this product

Product Details

September 30, 2011
File Format
File Size
7.87 MB
Product ID

Formats for this Ebook

Required Software Any PDF Reader, Apple Preview
Supported Devices Windows PC/PocketPC, Mac OS, Linux OS, Apple iPhone/iPod Touch... (See More)
# of Devices Unlimited
Flowing Text / Pages Pages
Printable? Yes
Report This Content to Lulu >

Moderation of Questionable Content

Thank you for your interest in helping us moderate questionable content on Lulu. If you need assistance with an order or the publishing process, please contact our support team directly.

How does this content violate the Lulu Membership Agreement?


Listed In

More From Hendrik Fuß