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An overview of comparative genomics and the analysis of sequenced genomes. Topics cover the recent methods used in the study of mobile DNA elements, motif finding and the characterization of segments within DNA sequences, theoretical considerations and techniques in the construction and analysis of sequence alignments, and the methods for processing microarray data. Also included is an overview of the computational issues involved in the study of the HIV virus. The last part of the book provides an overview of the resources and technologies aimed to facilitate core genomics research: databases and supercomputing applications, the focus being on emerging technologies such as the interconnecting of resources, the development of meta-databases and data exchange protocols. The book concludes with a review of networking technologies and resources, as well as some of the applications of distributed computing in genomics. An essential book for anyone involved in genomics or bioinformatics.