Search Results: ''

Search

×
×
×
×
1 results for ""
The Prion Protein By Jörg Tatzelt
Paperback: $206.53
Prints in 3-5 business days
Paperback: ISBN 978-1-912530-07-6 EAN 9781912530076 Highlights the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated... More > in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.< Less