Search Results: 'rna and protein'

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3 results for "rna and protein"
The Biophysical Chemistry of Nucleic Acids By Thomas Creighton
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This volume describes all the biophysical and chemical properties of the nucleic acids DNA and RNA: their structures and physical properties, the topological properties of DNA, and their sequencing... More > and synthesis, unfolding and hybridization, and binding to proteins. Color is used throughout to enhance the many illustrations. These chapters are taken from the larger volume "The Biophysical Chemistry of Nucleic Acids & Proteins" (2010, Helvetian Press, www.HelvetianPress.com).< Less
Internal Ribosome Entry Site (IRES) advances and applications By Shara Cohen
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Protein synthesis is a three-stage process, consisting of initiation, elongation and termination. The final stage of gene expression involves numerous cellular proteins and RNAs. The initiation step... More > is the primary focus for regulation. Translation initiation on the majority of cellular mRNAs is mediated by a mechanism involving recognition of the 5’ terminal cap-structure (m7GpppN). However, a different mechanism, termed internal initiation, was first shown to occur on certain uncapped viral mRNAs. An internal ribosome entry site (IRES) element present within the 5’ untranslated region (UTR) of the viral RNA directs initiation of protein synthesis at an internal position hundreds of nucleotides downstream from the 5’ terminus. IRES elements are highly structured and position the ribosome at, or just upstream of, the initiation codon. IRES elements have been found in certain cellular mRNAs; these generally encode proteins involved in apoptosis, cell cycle regulation or stress responses.< Less
Internal Ribosome Entry Site (IRES) advances and applications By Shara Cohen
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Protein synthesis is a three-stage process, consisting of initiation, elongation and termination. The final stage of gene expression involves numerous cellular proteins and RNAs. The initiation step... More > is the primary focus for regulation. Translation initiation on the majority of cellular mRNAs is mediated by a mechanism involving recognition of the 5’ terminal cap-structure (m7GpppN). However, a different mechanism, termed internal initiation, was first shown to occur on certain uncapped viral mRNAs. An internal ribosome entry site (IRES) element present within the 5’ untranslated region (UTR) of the viral RNA directs initiation of protein synthesis at an internal position hundreds of nucleotides downstream from the 5’ terminus. IRES elements are highly structured and position the ribosome at, or just upstream of, the initiation codon. IRES elements have been found in certain cellular mRNAs; these generally encode proteins involved in apoptosis, cell cycle regulation or stress responses.< Less