More From John Neville

Is a link between RPS27 and Talin an important missing link in the aetiology of Cystic Fibrosis? By John Neville
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The weight of evidence is that mucus production in Cystic Fibrosis (CS) is a downstream consequence of a mutation in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and not a direct... More > consequence. Here it is hypothesized that the pathway that impacts lung and airway mucus hyperaccumulation in CS may be via CFTR to RPS27 to Talin genes, particularly TLN1, to fibronectin and to MUC5B. This hypothesized cascade/pathway may play a functional role in cystic fibrosis mucus hyperaccumulation in the lung and airways. If this is the case, targeting Talin function may result in an effective life-extending treatment.< Less
The multiprotein complex which interacts with CD36 to generate the pre-chylomicron transport vesicle required for COP2 transport may be of significance in a familial disorder which causes psychosis and in schizophrenia more generally. By John Neville
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It was previously concluded that patterns of genes located at 17q25.3 (the location of PYCR1, SEC24D, the prolyl 4 hydroxylase subunit P4HB and CSNK1D) and 5q31.1 (the location of SAR1B, SEC24A, the... More > prolyl 4 hydroxylase subunit P4HA2 and, at 5q32, CSNK1A) were probably significant in a familial disorder that causes psychosis. This allowed for a prediction that there must be a direct link between PYCR1 function and SAR1B function, as well as a link between SEC24, PYCR1, SAR1B, prolyl 4 hydroxylase subunits and casein kinase 1. Here it is pointed out that CD36 provides this link. Additionally, it was previously noted that SAR1B mediated COP2 transport probably played a significant role in the familial disorder and in schizophrenia more generally. Further evidence is presented that suggests that a novel multiprotein complex which interacts to generate the pre-chylomicron transport vesicle required for COP2 transport is of significance in the familial disorder and in schizophrenia more generally.< Less
Mir190, perhaps via interactions involving TP53INP1, CBX4 and 14-3-3 proteins, may play a significant role in SEC24A/SEC24D and CSNK1A/CSNK1D COP2 interactions which may be of significance in the aetiology of schizophrenia. By John Neville
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It is proposed that in addition to regulating prolyl 4 hydroxylase, Mir190 could play a significant role in SEC24A/SEC24D as well as CSNK1A/CSNK1D interactions and could thus play a role in... More > regulating the COP2 transport process. It is suggested that this may be via the MIR190 target TP53INP1 and CBX4 (17q25.3) which SUMOlates TP53INP1. That this may take place was indicated by the fact that the prolyl 4 hydroxylase sub unit P4HA2, along with the COP2 transport genes SEC24A and SAR1B, is located at 5q31.1 (CSNK1A is located at 5q32); whilst the prolyl 4 hydroxylase subunit P4HB, along with SEC24D, CSNK1D and PYCR1, is located at 17q25.3. It is also proposed that the suggested interaction of MIR190 with SEC24 and CSNK1, perhaps via TP53INP1 and CBX4 and 14-3-3 proteins, may play a significant role in the aetiology of schizophrenia.< Less
The interaction of HIF1a, ammonia and NMDAR subunits is identified as a location of particular interest in schizophrenia, and MIR190a is identified as a candidate location for a familial disorder which substantially increases the risk of psychosis. By John Neville
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The interaction of HIF1a, ammonia and NMDAR subunits is identified as a location of particular interest in schizophrenia, and MIR190a is identified as a candidate location for a familial disorder... More > which substantially increases the risk of psychosis.< Less

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