This volume describes all the biophysical and chemical properties of the nucleic acids DNA and RNA: their structures and physical properties, the topological properties of DNA, and their sequencing and synthesis, unfolding and hybridization, and binding to proteins. Color is used throughout to enhance the many illustrations. These chapters are taken from the larger volume "The Biophysical Chemistry of Nucleic Acids & Proteins" (2010, Helvetian Press, www.HelvetianPress.com).