As a young theologian Schweitzer published The Quest of the Historical Jesus (1906), by which he gained a great reputation. In this book, he interpreted the life of Jesus in the light of Jesus' own eschatological convictions. Schweitzer demonstrated that 19th century "liberal lives of Jesus" produced by those who sought to reimage Jesus through historical study were reflections of the authors' own historical and social contexts. This work effectively ended for decades the Quest for the Historical Jesus as a subdiscipline of New Testament studies.

As a young theologian Schweitzer published The Quest of the Historical Jesus (1906), by which he gained a great reputation. In this book, he interpreted the life of Jesus in the light of Jesus' own eschatological convictions. Schweitzer demonstrated that 19th century "liberal lives of Jesus" produced by those who sought to reimage Jesus through historical study were reflections of the authors' own historical and social contexts. This work effectively ended for decades the Quest for the Historical Jesus as a subdiscipline of New Testament studies, until the development of the so-called "Second Quest," among whose notable exponents was Rudolf Bultmann's student Ernst Käsemann.