How comes that sometimes a remedy, obviously well chosen, works poorly? How comes that a well-chosen remedy sometimes gives terrible aggravations? Wrong potency, wrong dose, but is that really all? In today's world, we are confronted not only with diseases, acute or chronic, but with a slow intoxication and intoxination of our bodies and minds, a slow, subtle, insensible but all pervading and almost unavoidable poisoning: adulterated food, polluted water, polluted air, EMFs, vaccines, medications, drugs, etc... Detoxification has become a mantra of health; everybody offers a product or a technique, obviously better than anything else, of course, yet we see little permanent results. That is because there must be a physiological and clinical logic to it, which is rarely present. In this expanded edtion, I am presenting my 25 years of clinical experience and continuous research in that field. Almost any practitioner could find some approach that would be useful to his patients, but the main principle has to be respected: start by repairing the system, then enhance it, and finally detoxify properly.