CLINICAL REVIEW ARTICLES IN PHYSIO PHARMACOLOGY

Diabetes mellitus (DM) is a chronic metabolic disorder manifested by an enhanced blood glucose levels. DM is categorized into type 1 diabetes and Type 2 diabetes. Metformin is an anti-diabetic medication that is related to the biguanide class. Metformin is the first treatment for Type 2 DM because of its efficacy, safety and minimal risk of hypoglycemia. Sulfonyl ureas namely glipizide and glyburide activate insulin secretion from pancreatic beta cells. Meglitinides, like nateglinide and repaglinide also activate insulin secretion, but their action is short - lived compare to sulfonyl ureas. Thiazolidine diones (TZDs) along with pioglitazone and rosiglitazone activate insulin sensitivity particularly in peripheral tissues.