Nuclear Receptor Screening

Nuclear receptors (NRs) are a class of proteins responsible for sensing steroid and thyroid hormones and certain other molecules. There are 48 genes in the human genome that code for the NRs. The myriad molecular pathways modulated by NRs including but not limited to inflammation, lipid metabolism, apoptosis, extracellular matrix regulation, energy metabolism, and angiogenesis. These pathways’ processes can impact human health, such as general homeostasis, growth, and proliferation, which enable NRs to become the important therapeutic targets in the pathology of cancer, inflammation, and many other diseases for decades.