When New Orleans EMT Jolie Baptiste inherits her late grandmother's grimoire, she discovers the book is rewriting itself — with her name appearing in entries dated before she was born. As its prophecies begin coming true, rival practitioners and an ancient hunger older than the city itself close in on her across New Orleans, Memphis, the Carolina Lowcountry, and Senegal. To survive, Jo must master a legacy of rootwork where every working demands a price — and the final price may be her own past.