INFAMOUS CRIME BOSS RAMSEY WRIGHT HOLDS MANHATTAN HOSTAGE IN THE FAR FUTURE BY ORDERING HIS HIRED SOLDIERS TO DESTROY ALL 21 BRIDGES AND TUNNELS, BLOCKING ALL ACCESS TO THE ISLAND AND STRANDING MILLIONS. WITH DEADLY FORCE, THE HORIZON SOLDIERS CONTROL THE STREETS. A DEADLY VIRUS IS RELEASED BY RAMSEY ON THE MANHATTAN CITIZENS, KILLING THOUSANDS UNTIL A VACCINE IS CREATED, BUT THIS VACCINE HAS A SUPER-POWERED SIDE EFFECT.