Dependent Origination is the most important teaching that the Buddha uses to explain what dukkha [suffering, unsatisfactoriness] arises dependent upon and to provide a strategy for ending dukkha. Dependent Origination is often presented as linked list of dependencies, frequently numbering twelve items. But it is far more than just the twelve item linked list; the implications of the general case of “something arising dependent upon something else” are quite profound and lead to some of the deepest of all the Buddha's teachings.